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Patients with Type 2 diabetes who are either overweight or obese are an inherently difficult-to-treat patient population, the analyst says. 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Lilly broke ground on a $6.5 billion Houston manufacturing plant expected to be operational by 2030, the report also said. 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The underwriters have an option to purchase up to an additional 7.5 million shares from the selling shareholders.The company expects to have 320.9 million shares outstanding immediately after the offering, it said. 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