Ionis Pharmaceuticals

43.59

+0.04000.09%

Volume:1.16M

Turnover:50.02M

Market Cap:7.24B

PE:-12.53

High:43.79

Open:43.75

Low:42.63

Close:43.54

52wk High:86.74

52wk Low:42.63

Shares:166.18M

Float Shares:161.92M

Volume Ratio:0.55

T/O Rate:0.71%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:16.47

PE(LYR):-18.31

Loading ...

Overview Company News Filings

Nov 09, 2022

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers HK | Online Trading in stocks, bonds & ETFS","description":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","keywords":"tiger trading,tiger security,tiger broker hk,tigers co ltd,tiger trade hk,tiger brokers hk,stock broker,securities broker,online brokerage,hong kong broker,hk broker,online stock trading,online trading platform,stock trading platforms,trading application,stock trading,stock trading hong kong,buying stocks in hong kong,tiger brokers","social":{"ogDescription":"Discover Tiger Brokers HK, an online trading platform for stocks&ETFs, options&futures, bonds and crypto. Open an account to enjoy low commission trading today!","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.0a0bd8dc.png","ogUrl":"https://hk.tigeractivity.com/stock/IONS/filings?page=15"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"HKG","license":"TBHK","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals","latestPrice":43.58,"timestamp":1791223965600,"preClose":43.54,"halted":0,"volume":1156657,"delay":0,"changeRate":0.0009186954524574907,"floatShares":161921007,"shares":166184322,"eps":-3.48,"marketStatus":"Trading","change":0.04,"latestTime":"10-05 14:12:58 EDT","open":43.75,"high":43.79,"low":42.63,"amount":50024810.318389,"amplitude":0.026642,"askPrice":43.63,"askSize":139,"bidPrice":43.58,"bidSize":244,"shortable":3,"etf":0,"ttmEps":-3.48,"tradingStatus":2,"nextMarketStatus":{"tag":"Post-Mkt","tradingStatus":3,"beginTime":1791230400000},"marketStatusCode":2,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":43.54,"preHourTrading":{"tag":"盘前","latestPrice":43.73,"preClose":43.54,"latestTime":"09:29 EDT","volume":4384,"amount":191880.9944,"timestamp":1791206999999,"change":0.19,"changeRate":0.004364,"amplitude":0.010106},"postHourTrading":{"tag":"盘后","latestPrice":43.61,"preClose":43.54,"latestTime":"19:56 EDT","volume":459543,"amount":20007556.3465,"timestamp":1790985391928,"change":0.07,"changeRate":0.001608,"amplitude":0.001608},"volumeRatio":0.545855,"impliedVol":0.5513,"impliedVolPercentile":0.9243},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161921007,"roa":"-12.42%","roe":"-105.50%","lyrEps":-2.38125,"volumeRatio":0.54593,"shares":166184322,"dividePrice":0,"high":43.79,"amplitude":0.026642,"preClose":43.54,"low":42.63,"week52Low":42.63,"pbRate":"16.47","psRate":"8.29","week52High":86.74,"institutionHeld":0.92,"latestPrice":43.59,"committee":0.764045,"eps":-3.48,"divideRate":0,"volume":1156816,"delay":0,"ttmEps":-3.48,"open":43.75,"prevYearClose":79.11,"prevWeekClose":43.54,"prevMonthClose":44.65,"prevQuarterClose":44.65,"fiveDayClose":45.57,"twentyDayClose":58.09,"sixtyDayClose":58.25},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2026-07-29","symbol":"IONS","fiscalQuarterEnding":"2026/06","expectedEps":-1.09,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1785297600000,"reportTimeType":"pre","actualEps":-0.7},{"market":"US","date":"2026-04-29","symbol":"IONS","fiscalQuarterEnding":"2026/03","expectedEps":-0.89,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1777435200000,"reportTimeType":"pre","actualEps":-0.56},{"market":"US","date":"2026-02-25","symbol":"IONS","fiscalQuarterEnding":"2025/12","expectedEps":-1.31,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1771995600000,"reportTimeType":"pre","actualEps":-1.41},{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"Pre-MKt","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.24,"buy":0.56,"hold":0.2,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.56,"analysts":25,"updateTime":1787112000000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2026-10-02","current":-12.522989,"percent":0.792514,"low":-1664.931905,"twenty":-46.83029,"median":-17.982683,"eighty":-12.34613,"high":882.260453,"avg":-65.226559,"sd":366.227214,"marketCap":7312110168},"quantilePoints":[{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-19","current":-49.051939,"twenty":-36.458718,"median":-16.773398,"eighty":-9.930898,"marketCap":12574072128},{"date":"2025-12-26","current":-50.960181,"twenty":-37.51116,"median":-16.804783,"eighty":-9.964551,"marketCap":13063234795},{"date":"2026-01-02","current":-49.987104,"twenty":-38.080464,"median":-16.872737,"eighty":-9.994875,"marketCap":12813794230},{"date":"2026-01-09","current":-51.522544,"twenty":-40.33867,"median":-16.913584,"eighty":-10.055281,"marketCap":13207392005},{"date":"2026-01-16","current":-48.786554,"twenty":-41.579494,"median":-16.936559,"eighty":-10.101905,"marketCap":12506042883},{"date":"2026-01-23","current":-51.680511,"twenty":-42.352038,"median":-16.969214,"eighty":-10.147872,"marketCap":13247885603},{"date":"2026-01-30","current":-53.001116,"twenty":-43.304049,"median":-17.016336,"eighty":-10.177655,"marketCap":13586412084},{"date":"2026-02-06","current":-52.748369,"twenty":-43.896106,"median":-17.042828,"eighty":-10.276361,"marketCap":13521622327},{"date":"2026-02-13","current":-51.674193,"twenty":-45.89007,"median":-17.08842,"eighty":-10.365331,"marketCap":13246265859},{"date":"2026-02-20","current":-52.536693,"twenty":-46.437268,"median":-17.113581,"eighty":-10.415699,"marketCap":13467360905},{"date":"2026-02-27","current":-34.265449,"twenty":-46.808807,"median":-17.154283,"eighty":-10.419492,"marketCap":13055136075},{"date":"2026-03-06","current":-32.554417,"twenty":-46.808807,"median":-17.180856,"eighty":-10.419492,"marketCap":12415831546},{"date":"2026-03-13","current":-31.332977,"twenty":-46.808807,"median":-17.209871,"eighty":-10.419492,"marketCap":11949990075},{"date":"2026-03-20","current":-30.891179,"twenty":-46.808807,"median":-17.218631,"eighty":-10.419492,"marketCap":11781494224},{"date":"2026-03-27","current":-32.155933,"twenty":-46.808807,"median":-17.24834,"eighty":-10.419492,"marketCap":12263854896},{"date":"2026-04-02","current":-32.541423,"twenty":-46.808807,"median":-17.287579,"eighty":-10.419492,"marketCap":12410875786},{"date":"2026-04-10","current":-33.104499,"twenty":-46.808807,"median":-17.33251,"eighty":-10.419492,"marketCap":12625625400},{"date":"2026-04-17","current":-32.597731,"twenty":-46.808807,"median":-17.370954,"eighty":-10.419492,"marketCap":12432350747},{"date":"2026-04-24","current":-32.090963,"twenty":-46.808807,"median":-17.417852,"eighty":-10.419492,"marketCap":12239076094},{"date":"2026-05-01","current":-37.78562,"twenty":-46.808807,"median":-17.460406,"eighty":-10.419492,"marketCap":12355028686},{"date":"2026-05-08","current":-38.422456,"twenty":-46.808807,"median":-17.499692,"eighty":-10.425443,"marketCap":12563259507},{"date":"2026-05-15","current":-38.250612,"twenty":-46.808807,"median":-17.54086,"eighty":-10.441583,"marketCap":12507070238},{"date":"2026-05-22","current":-38.301154,"twenty":-46.808807,"median":-17.626193,"eighty":-10.45769,"marketCap":12523596493},{"date":"2026-05-29","current":-39.084564,"twenty":-46.821444,"median":-17.65446,"eighty":-10.515842,"marketCap":12779753455},{"date":"2026-06-05","current":-37.972628,"twenty":-46.808807,"median":-17.690774,"eighty":-10.584827,"marketCap":12416175832},{"date":"2026-06-12","current":-37.31052,"twenty":-46.808807,"median":-17.738974,"eighty":-10.668419,"marketCap":12199681883},{"date":"2026-06-18","current":-37.558179,"twenty":-46.808807,"median":-17.769888,"eighty":-10.69486,"marketCap":12280660536},{"date":"2026-06-26","current":-39.595044,"twenty":-46.821444,"median":-17.818766,"eighty":-10.726786,"marketCap":12946668637},{"date":"2026-07-02","current":-40.024656,"twenty":-46.821444,"median":-17.854581,"eighty":-10.726786,"marketCap":13087141809},{"date":"2026-07-10","current":-32.483705,"twenty":-46.821444,"median":-17.871767,"eighty":-10.726786,"marketCap":10621424474},{"date":"2026-07-17","current":-27.621511,"twenty":-46.821444,"median":-17.880886,"eighty":-10.979464,"marketCap":9031598685},{"date":"2026-07-24","current":-28.23813,"twenty":-46.821444,"median":-17.925673,"eighty":-11.109046,"marketCap":9233219003},{"date":"2026-07-31","current":-15.666504,"twenty":-46.83029,"median":-17.93492,"eighty":-11.257113,"marketCap":8854300676},{"date":"2026-08-07","current":-16.022293,"twenty":-46.83029,"median":-17.93492,"eighty":-11.326236,"marketCap":9055383705},{"date":"2026-08-14","current":-16.42807,"twenty":-46.83029,"median":-17.93492,"eighty":-11.457268,"marketCap":9284718070},{"date":"2026-08-21","current":-17.277849,"twenty":-46.83029,"median":-17.93492,"eighty":-11.52511,"marketCap":9764990760},{"date":"2026-08-28","current":-18.356979,"twenty":-46.83029,"median":-17.973741,"eighty":-11.565738,"marketCap":10374887222},{"date":"2026-09-04","current":-17.092603,"twenty":-46.83029,"median":-17.982683,"eighty":-11.643516,"marketCap":9660294637},{"date":"2026-09-11","current":-16.363381,"twenty":-46.83029,"median":-17.982683,"eighty":-11.688179,"marketCap":9248157519},{"date":"2026-09-18","current":-13.746416,"twenty":-46.83029,"median":-17.982683,"eighty":-11.837789,"marketCap":7769117053},{"date":"2026-09-25","current":-12.881936,"twenty":-46.83029,"median":-17.982683,"eighty":-12.071681,"marketCap":7280535146},{"date":"2026-10-02","current":-12.937804,"twenty":-46.83029,"median":-17.982683,"eighty":-12.34613,"marketCap":7312110168}],"updateTime":1791223978496},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:15,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"15643330","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122040624-IONS","pdf_url":"","pub_time":1667923200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122040624/0001140361-22-040624-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122040624/brhc10043925_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10043925_ex99-1.htm","type":"EX-99.1","id":"NTFILE9kN6fGisNg4wvS7M","market":"us","size":368474},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122040624/brhc10043925_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10043925_8k.htm","type":"8-K","id":"NTFILECX359S9msz99e2qw","market":"us","size":27899},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122040624/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILE41i9i7da7SikAoFe","market":"us","size":8345},{"description":"","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122040624/image1.jpg","primary":false,"translateUrl":"","linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILEJ43NbhgxkkEDnjWs","market":"us","size":803}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-11-09 00:00","pubTimestamp":1667923200,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15643329","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401522000168-IONS","pdf_url":"","pub_time":1667923200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q  - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q  - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/0000874015-22-000168-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q  - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 9-30-2022","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILE5pwAmCrrQgQMai99","market":"us","size":2092156},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILEDGZEg9eury8Sg2AW","market":"us","size":21066},{"description":"EXHIBIT 31.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/ex31-1.htm","primary":false,"translateUrl":"","linkName":"ex31-1.htm","type":"EX-31.1","id":"NTFILE6pPhqm2wr8qKdT5c","market":"us","size":12751},{"description":"EXHIBIT 31.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/ex31-2.htm","primary":false,"translateUrl":"","linkName":"ex31-2.htm","type":"EX-31.2","id":"NTFILEmeGbSXpgbjXfZb2C","market":"us","size":12644},{"description":"EXHIBIT 32.1","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000168/ex32-1.htm","primary":false,"translateUrl":"","linkName":"ex32-1.htm","type":"EX-32.1","id":"NTFILE41R6D1hR1Fnq4s3W","market":"us","size":6971}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2022-11-09 00:00","pubTimestamp":1667923200,"title_zh":"10-Q  - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15618834","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122039934-IONS","pdf_url":"","pub_time":1667491200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122039934/0001140361-22-039934-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.02: Termination of a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122039934/brhc10043749_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10043749_ex99-1.htm","type":"EX-99.1","id":"NTFILE5ViwdxGvcW9P85X6","market":"us","size":17448},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122039934/brhc10043749_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10043749_8k.htm","type":"8-K","id":"NTFILE3NrevhpFKwgt4YNJ","market":"us","size":28904},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122039934/image01.jpg","primary":false,"translateUrl":"","linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILEA65NQrbkjf9APMZo","market":"us","size":87473}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-11-04 00:00","pubTimestamp":1667491200,"title_zh":"8-K  - Current report","summary_en":"Item 1.02: Termination of a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15591141","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122038198-IONS","pdf_url":"","pub_time":1666540800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122038198/0001140361-22-038198-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 2.01: Completion of Acquisition or Disposition of Assets;\nItem 2.03: Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122038198/brhc10043182_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10043182_8k.htm","type":"8-K","id":"NTFILE8W38M6r2SNvvz1DX","market":"us","size":42991}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-10-24 00:00","pubTimestamp":1666540800,"title_zh":"8-K  - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 2.01: Completion of Acquisition or Disposition of Assets;\nItem 2.03: Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15531841","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122036895-IONS","pdf_url":"","pub_time":1665504000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122036895/0001140361-22-036895-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122036895/brhc10042856_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10042856_8k.htm","type":"8-K","id":"NTFILEF7ZMZ3hc3guWEW5T","market":"us","size":31326}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-10-12 00:00","pubTimestamp":1665504000,"title_zh":"8-K  - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15294190","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122028849-IONS","pdf_url":"","pub_time":1659974400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122028849/0001140361-22-028849-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122028849/brhc10040582_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10040582_ex99-1.htm","type":"EX-99.1","id":"NTFILE5nzknX4wPxSjxWj7","market":"us","size":351885},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122028849/brhc10040582_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10040582_8k.htm","type":"8-K","id":"NTFILEBHzPJH1JCu7B2e2C","market":"us","size":26937},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122028849/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEF4bo7LaKDoAftAnQ","market":"us","size":8345},{"description":"","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122028849/image1.jpg","primary":false,"translateUrl":"","linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILE6uX2naMaxgJX2MWB","market":"us","size":803}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-08-09 00:00","pubTimestamp":1659974400,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15294189","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401522000148-IONS","pdf_url":"","pub_time":1659974400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q  - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q  - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/0000874015-22-000148-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q  - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 6-30-2022","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILEwsQcTdvDDTrFfZzz","market":"us","size":2049633},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILEBWuLhpfdFPP2oYox","market":"us","size":75152},{"description":"EXHIBIT 31.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/ex31-1.htm","primary":false,"translateUrl":"","linkName":"ex31-1.htm","type":"EX-31.1","id":"NTFILEHCcp87s6y9Q7imsB","market":"us","size":12901},{"description":"EXHIBIT 31.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/ex31-2.htm","primary":false,"translateUrl":"","linkName":"ex31-2.htm","type":"EX-31.2","id":"NTFILE8rkedTbKLMeb2r26","market":"us","size":12794},{"description":"EXHIBIT 32.1","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/ex32-1.htm","primary":false,"translateUrl":"","linkName":"ex32-1.htm","type":"EX-32.1","id":"NTFILE6Lp17MZFaG1cBLHJ","market":"us","size":6990},{"description":"","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000148/image1.jpg","primary":false,"translateUrl":"","linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILEBkxsEi4jj8mSYqoF","market":"us","size":11357}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2022-08-09 00:00","pubTimestamp":1659974400,"title_zh":"10-Q  - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15237509","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122027187-IONS","pdf_url":"","pub_time":1658937600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122027187/0001140361-22-027187-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 3.01: Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122027187/brhc10040095_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10040095_8k.htm","type":"8-K","id":"NTFILEHGC1JVh8sARfzWY9","market":"us","size":21181}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-07-28 00:00","pubTimestamp":1658937600,"title_zh":"8-K  - Current report","summary_en":"Item 3.01: Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15206505","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122026294-IONS","pdf_url":"","pub_time":1658160000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026294/0001140361-22-026294-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026294/brhc10039775_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10039775_ex99-1.htm","type":"EX-99.1","id":"NTFILE7m7riseBp7CquNP9","market":"us","size":69206},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026294/brhc10039775_form8k.htm","primary":false,"translateUrl":"","linkName":"brhc10039775_form8k.htm","type":"8-K","id":"NTFILE4j1vK4r7C9y7eYba","market":"us","size":26808},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026294/brhc10039775_image1.jpg","primary":false,"translateUrl":"","linkName":"brhc10039775_image1.jpg","type":"GRAPHIC","id":"NTFILE56hiyN1Yx6bSHrrz","market":"us","size":18221}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-07-19 00:00","pubTimestamp":1658160000,"title_zh":"8-K  - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15206506","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122026165-IONS","pdf_url":"","pub_time":1658073600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026165/0001140361-22-026165-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122026165/brhc10039716_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10039716_8k.htm","type":"8-K","id":"NTFILEB9JDCnLNSBh7qqqv","market":"us","size":22205}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-07-18 00:00","pubTimestamp":1658073600,"title_zh":"8-K  - Current report","summary_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15177386","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122025669-IONS","pdf_url":"","pub_time":1657468800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122025669/0001140361-22-025669-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122025669/brhc10039557_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10039557_ex99-1.htm","type":"EX-99.1","id":"NTFILE2qiaZ1X8tiNNSfrg","market":"us","size":16884},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122025669/brhc10039557_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10039557_8k.htm","type":"8-K","id":"NTFILE74KVH6qhg8AaJbNu","market":"us","size":24994},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122025669/image1.jpg","primary":false,"translateUrl":"","linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILE62VSAyXUdJ5M4L3U","market":"us","size":4919}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-07-11 00:00","pubTimestamp":1657468800,"title_zh":"8-K  - Current report","summary_en":"Item 1.01: Entry into a Material Definitive Agreement;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15074713","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122023541-IONS","pdf_url":"","pub_time":1655740800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122023541/0001140361-22-023541-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122023541/brhc10038943_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10038943_ex99-1.htm","type":"EX-99.1","id":"NTFILE8Crf6nKwrHkTReQm","market":"us","size":21470},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122023541/brhc10038943_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10038943_8k.htm","type":"8-K","id":"NTFILE9V8maLpX8vdV2QbS","market":"us","size":24167},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122023541/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILEBtWv8u3AZeL2iJ5w","market":"us","size":4804}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-06-21 00:00","pubTimestamp":1655740800,"title_zh":"8-K  - Current report","summary_en":"Item 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"15007781","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122022009-IONS","pdf_url":"","pub_time":1654444800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122022009/0001140361-22-022009-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.07: Submission of Matters to a Vote of Security Holders;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122022009/brhc10038514_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10038514_8k.htm","type":"8-K","id":"NTFILEAYWp9yQ7gj3kzotd","market":"us","size":36522}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-06-06 00:00","pubTimestamp":1654444800,"title_zh":"8-K  - Current report","summary_en":"Item 5.07: Submission of Matters to a Vote of Security Holders;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14814187","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401522000104-IONS","pdf_url":"","pub_time":1651593600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-Q  - Quarterly report [Sections 13 or 15(d)]","symbol":"IONS","title":"10-Q  - Quarterly report [Sections 13 or 15(d)]","titleType":"Quarterly Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/0000874015-22-000104-index.htm","us_notice_code":"Form 10-Q","us_title_en":"10-Q  - Quarterly report [Sections 13 or 15(d)]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS INC 10-Q 3-31-2022","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/form10q.htm","primary":true,"translateUrl":"","linkName":"form10q.htm","type":"10-Q","id":"NTFILEGQr7YyuaGibdAN75","market":"us","size":1648222},{"description":"EXHIBIT 10.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/ex10-1.htm","primary":false,"translateUrl":"","linkName":"ex10-1.htm","type":"EX-10.1","id":"NTFILE9Mrft2nMBs85fKxW","market":"us","size":145789},{"description":"EXHIBIT 31.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/ex31_1.htm","primary":false,"translateUrl":"","linkName":"ex31_1.htm","type":"EX-31.1","id":"NTFILECMuNYVedbGSGEF9r","market":"us","size":13444},{"description":"EXHIBIT 31.2","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/ex31_2.htm","primary":false,"translateUrl":"","linkName":"ex31_2.htm","type":"EX-31.2","id":"NTFILECGKpxixTd8ZjYsjB","market":"us","size":13309},{"description":"EXHIBIT 32.1","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000104/ex32_1.htm","primary":false,"translateUrl":"","linkName":"ex32_1.htm","type":"EX-32.1","id":"NTFILEEAyc6SJR2nSLT8AQ","market":"us","size":7338}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Quarterly Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Quarterly Report","pubTime":"2022-05-04 00:00","pubTimestamp":1651593600,"title_zh":"10-Q  - Quarterly report [Sections 13 or 15(d","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14795125","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122017616-IONS","pdf_url":"","pub_time":1651593600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122017616/0001140361-22-017616-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122017616/brhc10037176_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10037176_ex99-1.htm","type":"EX-99.1","id":"NTFILE8dDh3jAk8BnPBNpJ","market":"us","size":282551},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122017616/brhc10037176_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10037176_8k.htm","type":"8-K","id":"NTFILE7h3CxYnxQyUA6HZY","market":"us","size":28551},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122017616/image01.jpg","primary":false,"translateUrl":"","linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILE9g3kTzZ15Eo6TTwY","market":"us","size":8345}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-05-04 00:00","pubTimestamp":1651593600,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14451897","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122010251-IONS","pdf_url":"","pub_time":1647792000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122010251/0001140361-22-010251-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"8-K","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122010251/brhc10035425_8k.htm","primary":true,"translateUrl":"","linkName":"brhc10035425_8k.htm","type":"8-K","id":"NTFILE3tMijbcyHPtKLef7","market":"us","size":33077}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-03-21 00:00","pubTimestamp":1647792000,"title_zh":"8-K  - Current report","summary_en":"Item 5.02: Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers: Compensatory Arrangements of Certain Officers;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14258999","market":"us","labels":[],"media":"sec.gov","original_id":"AN87401522000079-IONS","pdf_url":"","pub_time":1645718400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"10-K  - Annual report [Section 13 and 15(d), not S-K Item 405]","symbol":"IONS","title":"10-K  - Annual report [Section 13 and 15(d), not S-K Item 405]","titleType":"Annual Report","type":"usFinancials","url":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/0000874015-22-000079-index.htm","us_notice_code":"Form 10-K","us_title_en":"10-K  - Annual report [Section 13 and 15(d), not S-K Item 405]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"IONIS PHARMACEUTICALS, INC. 10-K 12-31-2021","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/form10k.htm","primary":true,"translateUrl":"","linkName":"form10k.htm","type":"10-K","id":"NTFILE9Nn6QsnGzqzn4du2","market":"us","size":4128050},{"description":"EXHIBIT 4.11","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit4-11.htm","primary":false,"translateUrl":"","linkName":"exhibit4-11.htm","type":"EX-4.11","id":"NTFILEAyPVnzfsAPHJwGei","market":"us","size":24552},{"description":"EXHIBIT 10.19","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit10-19.htm","primary":false,"translateUrl":"","linkName":"exhibit10-19.htm","type":"EX-10.19","id":"NTFILED6RKCma23jqxgQfB","market":"us","size":86819},{"description":"EXHIBIT 10.60","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit10-60.htm","primary":false,"translateUrl":"","linkName":"exhibit10-60.htm","type":"EX-10.60","id":"NTFILEH8DriEULJTPTyt9N","market":"us","size":46272},{"description":"EXHIBIT 10.83","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit10-83.htm","primary":false,"translateUrl":"","linkName":"exhibit10-83.htm","type":"EX-10.83","id":"NTFILEbdUWfXUFDrcZyiHa","market":"us","size":32094},{"description":"EXHIBIT 10.84","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit10-84.htm","primary":false,"translateUrl":"","linkName":"exhibit10-84.htm","type":"EX-10.84","id":"NTFILE3bS5CuF2Q9Yc9Jgv","market":"us","size":1557190},{"description":"EXHIBIT 21.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit21-1.htm","primary":false,"translateUrl":"","linkName":"exhibit21-1.htm","type":"EX-21.1","id":"NTFILE4pWdtipeEJPjFE5C","market":"us","size":3707},{"description":"EXHIBIT 23.1","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit23-1.htm","primary":false,"translateUrl":"","linkName":"exhibit23-1.htm","type":"EX-23.1","id":"NTFILE2tBPUVqvmXzggddo","market":"us","size":3047},{"description":"EXHIBIT 31.1","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit31-1.htm","primary":false,"translateUrl":"","linkName":"exhibit31-1.htm","type":"EX-31.1","id":"NTFILE91mZfaCMHyRx2j3M","market":"us","size":13081},{"description":"EXHIBIT 31.2","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit31-2.htm","primary":false,"translateUrl":"","linkName":"exhibit31-2.htm","type":"EX-31.2","id":"NTFILE5yCAWV4xeRhhMqSa","market":"us","size":13090},{"description":"EXHIBIT 32.1","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/exhibit32-1.htm","primary":false,"translateUrl":"","linkName":"exhibit32-1.htm","type":"EX-32","id":"NTFILEABsH9J97HyfdG4mW","market":"us","size":7653},{"description":"","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image01.jpg","primary":false,"translateUrl":"","linkName":"image01.jpg","type":"GRAPHIC","id":"NTFILEFSescUJGauauXXam","market":"us","size":167230},{"description":"","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image02.jpg","primary":false,"translateUrl":"","linkName":"image02.jpg","type":"GRAPHIC","id":"NTFILEGnJUW1AHbYn5bhfN","market":"us","size":24762},{"description":"","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image03.jpg","primary":false,"translateUrl":"","linkName":"image03.jpg","type":"GRAPHIC","id":"NTFILE8a9qRvu8zv5uwRop","market":"us","size":32540},{"description":"","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image04.jpg","primary":false,"translateUrl":"","linkName":"image04.jpg","type":"GRAPHIC","id":"NTFILE43FfASv7NRA9Y5PX","market":"us","size":46106},{"description":"","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image05.jpg","primary":false,"translateUrl":"","linkName":"image05.jpg","type":"GRAPHIC","id":"NTFILE4Eiu2ef7GttiES4t","market":"us","size":40315},{"description":"","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image06.jpg","primary":false,"translateUrl":"","linkName":"image06.jpg","type":"GRAPHIC","id":"NTFILEFopbyTDGZ5xqcji9","market":"us","size":67530},{"description":"","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image07.jpg","primary":false,"translateUrl":"","linkName":"image07.jpg","type":"GRAPHIC","id":"NTFILE3QFjVeKwCf8Dt1E9","market":"us","size":105188},{"description":"","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image08.jpg","primary":false,"translateUrl":"","linkName":"image08.jpg","type":"GRAPHIC","id":"NTFILE48ahu1BeaTDzwoZT","market":"us","size":49803},{"description":"","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image09.jpg","primary":false,"translateUrl":"","linkName":"image09.jpg","type":"GRAPHIC","id":"NTFILE24pBRbh2KHRVLEaK","market":"us","size":86992},{"description":"","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image10.jpg","primary":false,"translateUrl":"","linkName":"image10.jpg","type":"GRAPHIC","id":"NTFILE7FaRMzJ8StiUM8bq","market":"us","size":31669},{"description":"","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image11.jpg","primary":false,"translateUrl":"","linkName":"image11.jpg","type":"GRAPHIC","id":"NTFILE3zcjnqC9aAxAuQxF","market":"us","size":25608},{"description":"","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image12.jpg","primary":false,"translateUrl":"","linkName":"image12.jpg","type":"GRAPHIC","id":"NTFILEBNp7YPNK2aNZvYRd","market":"us","size":112488},{"description":"","seq":29,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image13.jpg","primary":false,"translateUrl":"","linkName":"image13.jpg","type":"GRAPHIC","id":"NTFILE2pChSHsNtbga6JMg","market":"us","size":73717},{"description":"","seq":30,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000087401522000079/image14.jpg","primary":false,"translateUrl":"","linkName":"image14.jpg","type":"GRAPHIC","id":"NTFILEFyjDkExCfQCsPQzr","market":"us","size":58301}],"type_name":"Financial Report","type_name_en":"Financial Report","titleTypeEn":"Annual Report","us_type":"财务报告","us_type_zh":"财务报告","earn_infos":[],"event_type":"important_notice","event_name":"Annual Report","pubTime":"2022-02-25 00:00","pubTimestamp":1645718400,"title_zh":"10-K  - Annual report [Section 13 and 15(d), not S-K Item 405","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14237418","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036122006515-IONS","pdf_url":"","pub_time":1645632000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"8-K  - Current report","symbol":"IONS","title":"8-K  - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036122006515/0001140361-22-006515-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122006515/brhc10034388_ex99-1.htm","primary":true,"translateUrl":"","linkName":"brhc10034388_ex99-1.htm","type":"EX-99.1","id":"NTFILE2a9uKdxz9nqRP2vV","market":"us","size":437285},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122006515/brhc10034388_8k.htm","primary":false,"translateUrl":"","linkName":"brhc10034388_8k.htm","type":"8-K","id":"NTFILEGsN3aD7vzPYgBMBr","market":"us","size":27920},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122006515/image0.jpg","primary":false,"translateUrl":"","linkName":"image0.jpg","type":"GRAPHIC","id":"NTFILEAMtPPMnwHCSSj6zY","market":"us","size":8345},{"description":"","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036122006515/image1.jpg","primary":false,"translateUrl":"","linkName":"image1.jpg","type":"GRAPHIC","id":"NTFILE3SqoPobs5DQ1GVo2","market":"us","size":803}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2022-02-24 00:00","pubTimestamp":1645632000,"title_zh":"8-K  - Current report","summary_en":"Item 2.02: Results of Operations and Financial Condition;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14176859","market":"us","labels":[],"media":"sec.gov","original_id":"AN119312522037224-IONS","pdf_url":"","pub_time":1644508800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000119312522037224/0001193125-22-037224-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SC 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000119312522037224/d294965dsc13ga.htm","primary":true,"translateUrl":"","linkName":"d294965dsc13ga.htm","type":"SC 13G/A","id":"NTFILE9zn3SHus5BnH9Uwu","market":"us","size":48215}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2022-02-11 00:00","pubTimestamp":1644508800,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"14176860","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465922017851-IONS","pdf_url":"","pub_time":1644422400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","symbol":"IONS","title":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","titleType":"Beneficial Ownership Change","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000110465922017851/0001104659-22-017851-index.htm","us_notice_code":"Form SC 13G/A","us_title_en":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"SCHEDULE 13G/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/102909/000110465922017851/tv01194-ionispharmaceuticals.htm","primary":true,"translateUrl":"","linkName":"tv01194-ionispharmaceuticals.htm","type":"SC 13G/A","id":"NTFILE873GwWGuQaPV7dJm","market":"us","size":11470}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Beneficial Ownership Change","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Beneficial Ownership Change","pubTime":"2022-02-10 00:00","pubTimestamp":1644422400,"title_zh":"SC 13G/A [Amend]  - Statement of acquisition of beneficial ownership by individuals","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":22,"pageCount":15,"totalSize":427,"code":"91000000","status":"200"}]}}